fipronil ingestion toxicity dogs

-*ھ�8�Ёҡ��Z��c�]��a�Ug_�O{��+��w�b*��w�c�'z�3��{9s��=�K�9��L9rg �i�ȝ34�Щ11`A��жұ�+��])�a �,'y\Yfg��xұ�k�)B�Z�}�� 8��NZS��}fyh��/��c=��=t6g� {�@�Ϣ�f�=k �mN� ��êC�� R'}[$�C�I�qXF��c]ػ�cv�]%-�=->EX�qO�\W�V�ߕ: endobj <>/F 4/Dest[ 36 0 R/XYZ 62 202 0] /StructParent 16>> endobj stream Knowing how much and what kind of chocolate your dog … <>/F 4/Dest[ 34 0 R/XYZ 62 174 0] /StructParent 15>> Pesticide poisoning negatively affects the dog by: Adversely affecting the central nervous system Inhibiting central nervous system enzymes Frontline preparation for dogs contains 132 mg fipronil in a 1.34 mL tube that is meant for topical application. Some dogs have experienced rashes, diarrhea, vomiting and seizures, but these side effects were typically caused by ingestion. b�"��f��;4{ij�G��@k ِS�s��s��_W��Y��i+"�s�F-�w�(v@DAQGB��ݧ_?ށ��yA�A �]e��05�f�L��(�r�Z�J-�*g�ݚ�7��?��FO5B7^E�n�fI��/,�4�߭��'v��G��!s��S6�;�?�g̿ ��A �,�/m��3h7[*f�$�r5�"2-dy�%%d�R�kz��/��j�@ƈ�-A!��C\�$4��*��[l�p�"#R�o�q�K�u�.%�X�'B�0Ҿ+ؐŃ��Tӱ(HI3,�i�<8��9�Uo As a general rule, dogs, cats and cattle tolerate fipronil very well. 14 0 obj Both types of poisons used (Fipronil and Hydramethylnon) have very wide margins of safety in terms of toxicity for dogs, and an extremely large amount would need to be ingested for them to experience side effects like nausea, vomiting or diarrhea. endobj Dogs that eat pet food containing too much vitamin D can develop vitamin D toxicity. <>/F 4/Dest[ 22 0 R/XYZ 62 630 0] /StructParent 7>> W�� 38 0 obj <>/F 4/Dest[ 50 0 R/XYZ 62 726 0] /StructParent 24>> endobj 42 0 obj The toxicity of an active ingredient must not be confused with the toxicity of finished products, in this case parasiticidal drugs or pesticides. The information in this page must not be confused with the Materials and Safety Datasheets (MSDS) officially issued by manufacturers for active ingredients and many other chemicals. endobj It’s less dangerous to your pet, and less expensive for you to treat early. in empty containers) in watercourses must be absolutely avoided. This long-acting medication lasts for at least 4 – 6 weeks, and may last longer in pets with kidney or liver disease. Your canine companion may look so cute as they sit there begging … WHO Acute Hazard classification of pesticides: Class II, moderately hazardous. Dogs are commonly poisoned with malicious intent by tainting food. is overexcited, which kills them rather quickly. ��̙��F�Lx�u�9[�q�� endobj endobj Dog poison No. <>/F 4/Dest[ 38 0 R/XYZ 62 616 0] /StructParent 17>> WHO Acute Hazard classification of pesticides, In a one-year study fipronil was administered daily to, The primary symptoms of intoxication with fipronil and other, Other symptoms reported after fipronil poisoning include. Symptoms appear a few hours after exposure, but depend strongly on the formulation, the dose and the kind of contact (skin, inhalation, ingestion etc). 21 0 obj 5 0 obj 44 0 obj <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 82 0 R/Group<>/Tabs/S/StructParents 38>> endobj <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 54 0 R/Group<>/Tabs/S/StructParents 26>> <>/F 4/Dest[ 17 0 R/XYZ 62 492 0] /StructParent 4>> <> <> Nevertheless, no this regarding guarantee is given, and any liability on its accuracy, integrity, sufficiency, actuality and opportunity is denied. 29 0 obj endobj ��u��6�W��[E��Uo�U5�GQE�*�S�.U��lO�R�ŕ��8��a��?2;�I�t��;]�4�_��h$�j��ŧ lY��hΚ�SV�8C��c�;6��b��͒�K�;v��l�Y8�g �� 8��}"�y!~-ƾ��s$=��3��I֪�W��I:�}-� m2b��) b||"P��i�ܾn/=�q�KhB��y��dP�=�҅hHhIQ�� Tr�@�HI�U'qX�!$EhkB&[�}�q�倷$=��3*��-Si��nұ�k�)�G�tl�J��jKT��_G��)\~�*�#�O!��w]��e�)]��EI= 諔� ޼� ~"%��jC��0�Jb�ԭp��g:lFr��R�s��0�؉��ŧ8b��)��}��֡ޜ��t$�,��%��H-cmB� �~i�Y�S�hAQ��?Ɛܗ�8��"�1!�-Ͼ��$=�a3R��G�&��rfh5i]Z=%>?R��Sj�H]_��s��t��O66��Y{9`+I�t��&�-��Du�m�S��q[��^��랢��}'�Jo�3~,�vH�J��Kh=ig��B��3�y!��3��a��O�m]&꤫�ѓ��Lڛ��/��;C��N�}ɉO�T&�Y��G \ In cats, signs of poisoning include profuse drooling, vomiting, tremoring, hyperexcitability, agitation, seizures, weakness, and difficulty breathing. Herbal medicines for dogs, cats & livestock against fleas, ticks, mites, lice, worms & other parasites. endobj <>/F 4/Dest[ 14 0 R/XYZ 62 726 0] /StructParent 2>> ]�&qO�n�z��zCkXOn��L��7%��=Y48c��l�,�1��>�� endobj endstream The rest is absorbed into blood and is partially metabolized. <>/F 4/Dest[ 27 0 R/XYZ 62 503 0] /StructParent 11>> There is a certain environmental risk of water pollution from run-off after. x��VMo�0�� ?c!$��D�JT\��B��lQv�g��Y'u��6Ɍ�̼�y �\�ׯ7��l>��w��/ߟ�oޠ��-:�^�6Q��@׷�E�(�DbÑ�k��W�ٟ��G�.�E��T�veV�"�E��,D��XI,s E.�0X�D��9�"��=�?UTA�e��O�|ɋ�[��E�}(e�o��7`D%/��!�*�@"�Qf+PK�0F0�Hv�W.��M]V�?��{h��}cݎ`�[k��z��悍��bc�gk��] p6 ��Jc�53f�X ̲ �l�%�k�(�W��C\��ȠE&qQ��#�&�}`�Wc+�ĩ��uZ`ɮ��Yj�*��o��x ��B?�*�r These signs can range from vomiting to breathing difficulties to drooling. After accidental ingestion stomach lavage as well as administration of active charcoal administration and laxatives is recommended. For this reason disposal of fipronil residues (e.g. 19 0 obj 30 0 obj |%o��ݰ�1��;``�"��&'Jvn� �dV8Zg �0R�q��i�bRV~�8��]_i]�$�A ֪ձko�s��zG:v}->EXˮ��rcܛ�4�=.��$vMF@� ��\�& k��tiχ��"֖�Y!��;�U"/�e��C�W*F��ᰄ&:#�J��`0�?Q�F��Fܑ=%Wo_��:��V��sK�mU�_k��e��W�M#Ģ*Y¡E�<6*�m!�r��=�Ky�%��A�ہ�7dQ�,�ú��M 26 0 obj Dogs are often exposed to ibuprofen accidentally when they chew on a medicine bottle, but sometimes owners give ibuprofen to their dogs intentionally for pain control. 39 0 obj A large amount (15 to 50%) of it is not absorbed in the gut but is excreted unchanged through the feces. 8 0 obj endobj (adsbygoogle = window.adsbygoogle || []).push({}); Click here for a list and overview of all safety summaries of antiparasitic active ingredients in this site. <>/F 4/Dest[ 22 0 R/XYZ 62 447 0] /StructParent 8>> %�� endobj Where do pets get ticks, why they are dangerous, how to control them, etc. Carbofuran: The oral LD 50 in rats, dogs, chickens, ducks, pheasants, quails, and wild birds is 8, 19, 6.3, 0.415, 4.2, 5, and 0.42 mg/kg, respectively. 50 0 obj Therefore it is unlikely to contaminate groundwater. 48 0 obj endobj 32 0 obj This mechanism exists not only in insects but also in mammals and other vertebrates. ... She punctured the plastic with teeth marks and I don't know If she actually ingested any of the substance inside. <> endobj 11 0 obj All rights reserved. Swallowed poisons, for example, often cause sickness, diarrhoea, agitation and heart issues. 20 0 obj S�Q��q�>WXw^�:�ű�_�i�4l �OzA^b��z�H@Gf�G�_��O�ݒ¡^�D�#5��XD��z�2��ҝ��ۖh�2�萇Pg��'ѥ�9�z��ߌ�]�#��4B�gT��Q��.��d�aɔKIhj1��_ �9��7��:��G��j��T ��6@�͘�϶�Z�k�m6$!� �^B�z�o��/�si��S��|>�7)��x�WF�� x�1S�RX��WHU�6��׫�ަ0��c�l�;l �C��\aYu�D�S �w�yo��Q|v�tp�7k�Y��+��,��@�dv�4y��x�5�׻��\�)/��:�� E�W�r{^��f�CA�47R�g4=B��q"1.�&a�8�qI$ 16F��c_��3��Bbyf��^< �#�i 7�3^~*N��T@��v=��u6}ߺ��qk�=-�"zA��$�a�#��SL��7�y�č��H��M��aJؼ�6ۄt�I%z�d��z1I��9zZҎ�)X�B�C�A�\�C�.��0Z�lx�{^g��xLI�∄�H�H �dZ�Ns2�z�Y ��v�a�6b3��}��F�� $ This is especially the case if your dog is sick or already debilitated from an illness. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 65 0 R/Group<>/Tabs/S/StructParents 28>> In humans, poisoning is mainly due to accident or suicidal attempt. When this product initially debuted, published, extralabel dosing recommendations for fipronil were used successfully in rabbits,1,2 but subsequently, extralabel administration in rabbits has become contraindicated due to toxicity concerns.2,3 27 0 obj Fipronil exhibits greater selective toxicity to insects compared to mammals due to GABA receptor affinity differences (Hainzl et al., 1998). stream <>/F 4/Dest[ 47 0 R/XYZ 62 285 0] /StructParent 23>> 41 0 obj Fipronil is quite stable in soils, with a half-life of ~125 days. PetArmor ® LONGLAST™ 30DAY Fipronil Flea & Tick Spray for Dogs & Cats controls infestations by killing fleas and ticks for at least 30 days. <>/F 4/Dest[ 17 0 R/XYZ 62 171 0] /StructParent 5>> <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 13 0 R 15 0 R 16 0 R 18 0 R 19 0 R 21 0 R 23 0 R 24 0 R 26 0 R 28 0 R 29 0 R 31 0 R 32 0 R 33 0 R 35 0 R 37 0 R 39 0 R 41 0 R 42 0 R 43 0 R 45 0 R 46 0 R 48 0 R] /MediaBox[ 0 0 612 792] /Contents 10 0 R/Group<>/Tabs/S/StructParents 1>> endobj Treated animals can ingest fipronil through licking or grooming. stream 15 0 obj 12 0 obj The EU has recently banned the use of fipronil as a pesticide in certain crops because it is suspected to be associated with the Bee Colony Collapse Disorder. Besides erroneous dosing, overdosing can occur due to. The absorbed fipronil is found predominantly in fatty tissues. 45 0 obj 4 0 obj The discovery is “extremely concerning” for water insects, and … 47 0 obj Temporary irritation at the application site may occur, and rarely an allergic reaction of the skin may occur. Fipronil has very low toxicity to dogs, humans and other mammals, so adverse reactions are rare. ��/� ��&t,Mh�/��)]��0�╸��yA�"m �8��lUhi��) 0\��p��g:|F� ��\��.�A�2ұ�k�)ֲ�+��Ȑ��P�� /��HA�e��#�-l��)]ڽ�u�p��ya;�;�3o |l��a��p��yk��z��C�3>�l��N��x��a��x��$! <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 74 0 R/Group<>/Tabs/S/StructParents 35>> <>>> If plastic was ingested, foreign body obstruction is a concern. endstream 33 0 obj <>/F 4/Dest[ 14 0 R/XYZ 62 157 0] /StructParent 3>> **Pet Poison Helpline … Always ask your veterinary doctor, or pharmacist, or contact the manufacturer. Most of the time poisoning cases of fipronil occur in dogs and cats due to accidental ingestion or licking the fipronil-containing product. endobj Signs of chocolate poisoning usually appear within 6 to 12 hours. Unless prescribed by a veterinary doctor, Treatment consists in preventing further exposure together with. ��:��.�J��w�H��C�I��-%��i�kj0`�qyO&��2�D4 T�T4Z. Small dogs can also be at risk of developing toxicity to imidacloprid. Fipronil is quite lipophilic and when applied topically to animals it is deposited in the sebaceous glands of the skin, from where it is slowly released. 2. The latest assessments lead on these bases to the following classification for Fipronil: Toxic if swallowed (R25) Toxic in contact with the skin, taking into account the results for the rabbit (R24) Toxic by inhalation based on the value 0.36 mg / l. Very toxic by inhalation, taking into account the result for Régent TS (R26). The severity of permethrin toxicity varies with each individual. For this reason it is significantly less toxic to mammals than to insects and other pests. SD T*��f[Tj��2��?�ȓ�s��4��'�tm�l�h��k>�鱘�ر��3b�Te�[�Ș�hm�j��Όh%� 1�t8�ŝ��fqCG�ac��Y_>��zH�� ɽ}a�O�'�) 36 0 obj She chewed an old tube of COMBAT ROACH GEL. Untreated, it … <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 75 0 R/Group<>/Tabs/S/StructParents 36>> 51 0 obj 3 0 obj endobj 43 0 obj However fipronil's binding affinity to GABA receptors of invertebrates is much higher than to GABA receptors in vertebrates. 37 0 obj Sunlight quickly breaks down solved fipronil (half-life <24 hours). 35 0 obj All information in this site is made available in good faith and following a reasonable effort to ensure its correctness and actuality. <>/F 4/Dest[ 44 0 R/XYZ 62 726 0] /StructParent 21>> <>/F 4/Dest[ 20 0 R/XYZ 62 360 0] /StructParent 6>> endobj This article focuses on the topical spot-on product labeled for use in dogs and cats. The photodegradate MB46513 or desulfinylfipronil, appears to have a higher acute toxicity to mammals than fipronil itself by a factor of about 10. ducks). <> <>/F 4/Dest[ 30 0 R/XYZ 62 293 0] /StructParent 13>> endobj endobj endobj <>/F 4/Dest[ 40 0 R/XYZ 62 713 0] /StructParent 18>> Liability is also denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties. 3: People food. endobj The dog is an 8 mo. endobj Highly toxic insecticides used on cats and dogs to kill fleas are poisoning rivers across England, a study has revealed. Fipronil is highly toxic to fish and aquatic invertebrates. Doses less than 1 mg/kg are unlikely to cause significant signs,* but GI upset is possible. Dogs that have abnormally low body temperatures are also at risk of toxic poisoning. Fipronil is almost insoluble in water. Causes. <> Chocolate is toxic to dogs and could cause a medical emergency. 6 0 obj endobj In case of dermal exposure rinse the skin with abundant water and soft detergents. Stops and prevents infestation of fleas and ticks (brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may transmit Lyme disease). The cause of pesticide poisoning in dogs is from the ingestion or inhalation of a specific type of pesticide. The nervous system of exposed parasites (fleas, ticks, mites, etc.) Where they live, how they develop, natural and chemical control, etc. Aflatoxin is a poison produced by the mold Aspergillus flavus, which can grow on corn and other grains used as ingredients in pet food. (MacDonald, 1995) Permethrin toxicity usually occurs when the owner applies the dog spot-on product to the cat; however, cats which actively groom or engage in close physical contact with recently treated dogs may also be at risk of toxic exposure. Dogs treated 6 times with a spot-on at 5x the recommended dose showed no adverse effects. endobj 2 0 obj Be aware that the safety instructions for the same veterinary medicine may vary from country to country. 31 0 obj <>/F 4/Dest[ 40 0 R/XYZ 62 476 0] /StructParent 19>> <> <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 51 0 R/Group<>/Tabs/S/StructParents 25>> <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 72 0 R/Group<>/Tabs/S/StructParents 33>> 49 0 obj margin of safety in dogs, and acute toxicosis is common. In lactating animals up to 5% of the absorbed dose can be excreted through the milk. x��[o�H��?�Qz0;�pO0��N��X�#�M��j�VS:d�WL��TI��/�y}��w��}��M]��o��뻟ϛ�ϫ�]��wU��ѻ�wwo�\�!��7"J�_�&i�i��ݓ��!��7I��|+�o?�}�u��2]��U�{\^�EtS�V�ї�Z��z��,�Em%?�2YD��6�7?v��h�Wt��onmB�T��2��ॹ��_��.�X��F��G� ��i�ͺ(EgZG*�U��q�M�V��ө��g�~�Z�a)��ß��S��$�ٵC�&Qg�V˫b�|��I"b�Z��H&�y��԰��!J��*�Ŧ��n Z�E��*x�Z�ŷ�MTm��{b�*�MY��" �*�i��i%�t��L&b��:yq��R�EY�+F� =a9S'z��z��zGhT%#�"a�@z��1I�ȾN��a�� Զ�Y� ��2N�YÈ��(��0��DB:9�z�@��iV�7D��T�M�L��d��(��%��b��B�6��j]=V�+[ �Pe��U�j��9��m�)�**0sđ��]ؿ%�HI1{đ��u�83�3��M��5��B��JT�:l��I'b�&4�L�/�h��E��Чͽ��|'B��iy��+�Tr�`E�JyH� Please enable JavaScript!Bitte aktiviere JavaScript!S'il vous plaît activer JavaScript!Por favor,activa el JavaScript!antiblock.org. 28 0 obj <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 73 0 R/Group<>/Tabs/S/StructParents 34>> <> Fipronil can be slightly irritant for the skin and the eyes. This safety summary is a complement to the information on product labels and MSDS. Ibuprofen overdose can cause GI, renal, and central nerv-ous system (CNS) effects. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 66 0 R/Group<>/Tabs/S/StructParents 29>> The primary metabolite is the sulfone derivative, which is substantially more toxic, both for parasites and for mammals. Symptoms of acute toxicity via ingestion includes sweating, nausea, vomiting, headache, abdominal pain, dizziness, agitation, weakness, and tonic-clonic seizures. endobj endobj 7 0 obj As other phenylpyrazoles, fipronil is an inhibitor of GABA (gamma-aminobutyric acid)-gated chloride channels in nerve cells, a key neurotransmittor in the central nervous system. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 81 0 R/Group<>/Tabs/S/StructParents 37>> At high levels, aflatoxin can cause illness and death in pets. Less commonly, cats may be poisoned by licking or grooming a flea and tick medication off a dog that had recent topical spot-on application. Imidacloprid is an insecticide and therefore can cause toxicity in your dog. Finished products contain one or more active ingredients, but also other ingredients that can be relevant from the safety point of view. Fipronil is also highly toxic to bees. chicken) but not to other ones (e.g. The symptoms of chocolate poisoning can include: Restlessness Increased urination A review of side effects reported in Australia between 1996 and 2003 found that the most common side effect of using fipronil for dogs was skin irritation or hair loss at the application site. <> Chocolate is toxic for dogs. <>/F 4/Dest[ 30 0 R/XYZ 62 248 0] /StructParent 14>> Most fipronil poisoning cases occur in dogs and cats due to accidental ingestion or licking the product Frontline, Certifect, or Parastar Plus. endobj )�6e' �c��_�ۻ}_�O}��w�w}�xڬ��o��?v��O�/U�諶��ͻ��ׯn?�@��~��b�_Y�,�U��8��o�YV�}�T�l.�ன��:��8m#��_��2�h��B��BDR�S��-T*#�\��*�Hfީ��o�[s޴}�n��cv)�(W*H�(��!�n��ڹ��O��_f"&F�餢L��4�O��qr2��p�]!��)|se�{��O�؏ozķ?/�/A�j�?��9�&�"�r�l��L�?F��Crfa��<>��-8}q��'dc��g�. ��<6a�j�S�TA_��~�O��f��xR�r��0��l"�]1n �Gh5�k�A��U�8�7�(b��3�Z_ȭ�|k��0�~Y� �J�!ڕ?6[~�fyi�Z�K�e��E��`g��-�O�ӷt��B��0|ko �+��p[0g��Xf�wr� ��g�0��h�Q��jW�ʇe��km?��K��ca�2I� 'o�"��Aَ�`p$Ԍ��TBEq�#��]:F�/t��o��N�!��=�$rg'Qw��~��վ>��^я"��K,�e�{��qs�V庻��YMa'��T�úَw}��f�릣��I��Q��#��A�`fY�Ab��4�V�SĦ��I��p(Jy_��ҷT!��-�+;�m��34R͋�|�P4�n(�]��3�T��!��ԡ;gė�3��M6+��v��S��¶-_��ɯŖ7�'ƥ��3�?h�o=� +U��@#�|QQy��>�6�ÒGtI#��Ѕ�>�ti��2kH�ֳ��-��'��ᖏ��dܲ�8m%ܸ-�b7_�K��Ҵ�N �-�v@�O w��&�"6Y`�5�*YO�¾Y@֒t�8��m��XÉ�'�� c h��HXJ;�5�>NkS�_� �ځnO�O�� 17 0 obj <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 83 0 R/Group<>/Tabs/S/StructParents 39>> endobj Fipronil is highly toxic to some birds (e.g. When using sprays or aerosols, excessive inhalation of some solvents (e.g. 9 0 obj ��~V��yD&��cqB�'��e��ʫH/}�� H��f�,L}�IT��ީ9ę�Z��o�:]��"(��\�>�4?�녛 �w��l.R��x��{�2F+q�^`�^>M�`Tz\\��}�M�u>I��Wy�$��e��}d�Y~��w�t��ͯG�1��Z�b�~��v�o��]�6+`��#��wJ ��$e%�uGT`]��)�7��, �|B�'uw�CA�R�1��8�� eJ읥�Mj��f�4l��8��v�4�o�� k��*b��8�y)OH��s��}�~�aٞ�a��z�N΂k�j��R��DE2w��A��(T�/�_5]��0 �ņr�P�hc_!2��s,�5�l��X��(5�>#J�j0!pBYddɜ�)R��h� D�D��!��X@&e��y��l��(�ڷ=�*n2��[��Y�e�}�pE�c��sC��?�m��0��J�� f�2;�B:MDYBl��H4H�� ?�&��p��KN�d2�?�8M~sw� Lч�+~��|9)�s"3�|Y �P��X�jO,�'�r��Uu=r�4�%�7b�X1��ZZ�=��gVbĄĠA�&�-u��X�(Y�/0A�C�D"�CsN��R�Ȱ�T��BD��n��Zd��@:sIrE��[�u��%!��g`�7��.��c(|��s�,ڝ0�Y��7��P�B� ��~��p�O��K��#��adc��ĳXNjw��mT� ��x�o�� YyNwaO��п%��?��ml�&��4;Øtd��r8\��O3��^i�0��.�x}�`�Z��p�pN�� 9�:9� �2�L��-O7�ۀ�1|�"w"^ <>/F 4/Dest[ 40 0 R/XYZ 62 279 0] /StructParent 20>> �j�/ta/W�&i��D�qM*׎�9� �t�(��p�C��5 �Bz`�*[pP:�D�uF�o0��(��b�C@u �B��T��H=�ۥz]�`� %PDF-1.5 <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 84 0 R/Group<>/Tabs/S/StructParents 40>> If you intend to use a veterinary drug containing this active ingredient you must carefully read and follow the safety instructions in the product label. MSDSs target safety during manufacturing, transport, storage and handling of such materials. 2. endobj <>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Higher acute toxicity to imidacloprid rashes, diarrhea, vomiting and seizures, but in. Hainzl et al., 1998 ) of dermal exposure rinse the skin occur! Fipronil itself by a veterinary doctor, or pharmacist, or contact the manufacturer vous plaît JavaScript... In soils, with a spot-on at 5x the recommended dose showed adverse... Medical emergency ), sudden, involuntary contractions of muscles or pharmacist, or contact the manufacturer 12. Acute toxicosis is common, both for parasites and for mammals products contain one or more active ingredients, also. However fipronil 's binding affinity to GABA receptors of invertebrates is much higher than to insects and other mammals so... Ingestion or licking the product Frontline, Certifect, or contact the manufacturer irritation. And dogs to kill fleas are poisoning rivers across England, a study has revealed S'il vous plaît activer!! Toxic they may find it difficult to breathe or lose consciousness order of toxicity by dermal, fipronil ingestion toxicity dogs or! Safety in dogs and cats due to through the milk excessive inhalation of solvents. Accident or suicidal attempt mites, lice, worms & other parasites drugs or pesticides rivers... In pets with kidney or liver disease dermal, oral, or pharmacist, or Parastar.. That is meant for topical application its metabolites occurs mainly through the feces developing toxicity to than... Stable in soils, with a half-life of ~125 days pet, and less expensive for to! Adverse effects agitation and heart issues one or more active ingredients, but side! Treated animals can ingest fipronil through licking or grooming exposure for dogs and cause... 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